Journal article
Targeting bromodomain-containing proteins to prevent spontaneous preterm birth
R Lim, C Nguyen-Ngo, M Lappas
Clinical Science | PORTLAND PRESS LTD | Published : 2019
DOI: 10.1042/CS20190919
Abstract
Preterm birth is a global healthcare challenge. Spontaneous preterm birth (sPTB) is commonly caused by inflammation, yet there are currently no effective therapies available. The Bromodomain and Extra-Terminal motif (BET) proteins, Bromodomain-containing protein (Brd) 2 (Brd2), Brd3 and Brd4 regulate inflammation in non-gestational tissues. The roles of Brd2-4 in human pregnancy are unknown. Using human and mouse models, the present study has identified the Brd proteins part of the process by which inflammation induces parturition. Using human clinical samples, we demonstrate that labor and infection increase the expression of Brds in the uterus and fetal membranes. In primary human myometri..
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Awarded by Austin Medical Research Foundation
Funding Acknowledgements
This work was supported by the Research Fellowship from the Department of Obstetrics and Gynaecology (University of Melbourne) (to Martha Lappas); the Faculty Fellowship from the University of Melbourne (to Martha Lappas); the Australian Government Research Training Program (RTP) Scholarship (to Caitlyn Nguyen-Ngo); the National Health and Medical Research Council (NHMRC) [grant number 1058786]; the Austin Medical Research Foundation; the Norman Beischer Medical Research Foundation; the University of Melbourne; and the Mercy Research Foundation. The funders had no role in study design, data collection, data analysis, interpretation and writing of the report.